NIH Director's Transformative Research Award

Grants to USA and territories scientists and groups of scientists affiliated with IHEs, nonprofit and for-profit organizations, and government agencies for innovative and unconventional scientific research. Applicants are advised that required registrations may take up to six weeks to complete. Funding is intended to support original research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies.
The award supports applicants proposing transformative projects that are inherently risky and untested but have the potential to create or overturn fundamental paradigms and may require very large budgets. Researchers from diverse backgrounds, including individuals from underrepresented racial and ethnic groups, individuals with disabilities, individuals from disadvantaged backgrounds, and women are strongly encouraged to work with their institutions to develop applications for this Funding Opportunity Announcement.Applications are welcome in all topics relevant to the broad mission of NIH, including, but not limited to, topics in the behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research. Research may be basic, translational, or clinical. The primary requirements are that the research be highly innovative and have the potential for unusually broad impact.Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director’s Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) Program of the NIH Common Fund.